The concept of sustainable job performance is at growth stage and researchers have been trying to conceptualize sustainable job performance and struggling to understand how the smart workplace predicts sustainable job performance. In this context, the purpose of this study is to examine the influence of attitude towards smart systems, technology readiness, perceived usefulness and the practicality of medical applications on the adoption of smart systems and the health workers’ sustainable job performance. Data was collected from 217 health workers working in hospitals and health centers in Saudi Arabia. Structural Equation Modeling (SEM) with Amos 16 was used to analyze the data. The results of the study indicated that the adoption of smart systems mediates the relationships between the attitude towards smart systems, technology readiness, perceived usefulness and the practicality of medical applications and the health workers’ sustainable job performance. The findings of this study will be helpful for policy makers and the management of organizations in the health sector for adopting practices based on the smart workplace and in achieving  the health workers’ sustainable job performance.